During the last years, except from the traditional CPU based hardware servers, hardware accelerators are widely used in various HPC application areas. More specifically, Graphics Processing Units (GPUs), Many Integrated Cores (MICs) and Field-Programmable Gate Arrays (FPGAs) have shown a great potential in HPC and have been widely mobilised in supercomputing and in HPC-Clouds. This presentation focuses on the development of a cloud simulation framework that supports hardware accelerators. The design and implementation of the framework are also discussed.